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Müller cells are the most abundant type of glial cells found in the vertebrate retina, and perform diverse functions that support the activity of retinal neurons. Muller Cells and the glial network The Muller cell would perform a dual purpose, passively transducing in the form of pressure changes the phase related data from light as it passes through the cell while simultaneously channeling and condensing the light spread to the photo intensity receptors (cones and rods) at the back of the retina. Mueller cells are important for glutamate metabolism (in the uptake of the transmitter released by photoreceptors), as well as for the storage of calcium ions. Damage to glial cells, e.g.

Microfluidic, label-free enrichment of prostate cancer cells in blood based on acoustophoresis PB Muller, M Rossi, AG Marin, R Barnkob, P Augustsson, T Laurell, . does not impact survival or function of microglia, leukocytes or tumor cells. av M Bouwens · 2009 · Citerat av 342 — fatty acids can have beneficial effects on human immune cells, such as peripheral blood mononuclear cells (PBMCs). Michael Müller,. av HY Yhim · 2017 · Citerat av 2 — CD11b+CX3CR1+ cells were analyzed by flow cytometry using peripheral blood by IL-10 [15, 20], suggesting that CD11b+CX3CR1+ cells function as MDSCs. Delabie J, Ott G, Muller-Hermelink HK, Campo E, Braziel RM, Jaffe ES, Pan Z, Biological process, Molecular function, Disease Mucus-secreting cells, Muller glia cells, Pancreatic endocrine cells, Paneth cells, Peritubular cells, Proximal ERK5 functionally links ALK signaling to MYCN expression in Goldring, J. Müller, M. J. Cross, ERK5: Structure, regulation and function.

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DISCUSSION In this study, we established the experimental conditions to isolate and expand a homogenous population of human and mouse adult MGCs. 2010-09-08 · Muller cells are specialized glial cells that are found in the retina of the human eye. Although they function as any normal glial cells, it has been seen, after an injury to the retina, that Müller cells undergo dedifferentiation into multipotent progenitor cells. 2008-11-03 · A direct survival function for VEGF was demonstrated using a Müller cell line as well as primary photoreceptor cells and sheets.

TRANSACTIVATION - Avhandlingar.se

They do not belong to the more esteemed family of neuronal cells but to the glia, a family of cells that until recently were seen as mere filling material between the neurons. Now, however, all that has changed. Se hela listan på hindawi.com Poorly recognized by anatomists and pathologists is the cone-shaped zone of Müller cells that composes the central and inner part of the fovea centralis. The importance of these cells in the structural integrity of the macula, as a repository for xanthophyll, and in the pathogenesis of macular These events alter the structure and function of the retina and involve to a large extent, Müller cells which seem to serve as pathways for neuronal migration. This paper by Karin Roesch , Michael B. Stadler and Constance L. Cepko looks at gene expression changes in the Müller cells, one of the glial cells of the retina as the rd1 mouse retina degenerates. muller cells.

Psychological and av JY Vargas · 2014 · Citerat av 127 — To study the role of Wnt signaling in the cognitive function of adult mice, we used Exp Cell Res 297:186–196, doi:10.1016/j.yexcr.2004.02.028, pmid:15194435.
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However, following injury to the retina, it has been shown in zebrafish that Müller glia undergo dedifferentiation into multipotent progenitor cells. Müller cells are also responsible for the maintenance of the homeostasis of the retinal extracellular milieu (ions, water, neurotransmitter molecules, and pH). In vascularized retinae, Müller cells Thus Muller cell functions include: Supplying endproducts of anaerobic metabolism (breakdown of glycogen) to fuel aerobic metabolism in the nerve cells. They mop up neural waste products such as carbon dioxide and ammonia and recycle spent amino acid … The homeostasis and metabolic health of the retina relies significantly on Müller cells, which span the entire retina and are mediated between the vessels and neurons. 1 While research has uncovered many consequences of Müller cell dysfunction, particularly with the cell’s function as a glucose processor, little is known about the cells’ biology based on their location within the retina.

This paper by Karin Roesch , Michael B. Stadler and Constance L. Cepko looks at gene expression changes in the Müller cells, one of the glial cells of the retina as the rd1 mouse retina degenerates. Muller cells are macroglia and play many essential roles as supporting cells in the retina. To respond to pathological changes in diabetic retinopathy (DR), a m Functions of Müller cell-derived vascular endothelial growth factor in diabetic retinopathy. The purity of the Müller cell cultures was characterized after each passage by testing for the expression of vimentin, AQP-4, GS, and CRALBP (Bunt-Milam and Saari, 1983). Müller cell CM was generated by culturing confluent wild-type or sEH −/− Müller cells for 48 h.
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Müller cells, the major type of glial cells in the retina, are responsible for the homeostatic and metabolic support of retinal neurons. By mediating transcellular ion, water, and bicarbonate Müller glia, or Müller cells, are glial cells found in the retina, which serve as support cells for the neurons of the retina as all glial cells do. However, following injury to the retina, it has been shown in zebrafish that Müller glia undergo dedifferentiation into multipotent progenitor cells. In addition, glial cells are of importance in signal processing, cellular metabolism, nervous system development, and the pathophysiology of neurological diseases. The Müller cell of the ver- brate retina provides a splendid example of an accessory cell that exhibits features illustrating every aspect of the complex behavior now associated with glial cells.

ERK5 functionally links ALK signaling to MYCN expression in Goldring, J. Müller, M. J. Cross, ERK5: Structure, regulation and function. Cell. av T Hatzihristidis · 2015 · Citerat av 9 — In the light of the work by Muller et al. important function for Drosophila Pez in intestinal stem cells by acting on the Hippo signaling pathway, Muller, P.B.; Rossi, M.; Marin, A.G.; Barnkob, R.; Augustsson, P.; Laurell, T.; acoustophoresis does not impact survival or function of microglia, MicroRNA biogenesis and function in single cell using scRNA-seq data.
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Effects of prolonged dark adaptation in patients with retinitis

By mediating transcellular ion, water, and bicarbonate transport, Müller cells control the composition of the extracellular space fluid. Müller cells provide trophic and anti-oxidative support of photoreceptors Müller cells are the principal glial cells of the retina, assuming many of the functions carried out by astrocytes, oligodendrocytes and ependymal cells in other CNS regions. Müller cells express numerous voltage-gated channels and neurotransmitter receptors, which recognize a variety of neuronal signals and trigger cell depolarization and intracellular Ca2+ waves.